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Our research focuses on understanding the mechanics of engineering and biological materials that are able to adapt and evolve their structure in response to external stimuli. This research ultimately finds application in the biomimetic design of smart materials, the engineering of artificial biological tissues and in fundamental advances in our understanding of biological cells and tissues (in both healthy and diseased states). Our approach relies on the development of novel multiscale mathematical and computational methods that can elucidate the interplay between mechanics, chemistry and transport phenomena across length-scales in materials’ microstructures. Specific research focuses on modeling of interactions of cells with their environment and the multiscale modeling of fracture in engineering and biological materials.