![Loren Hough Portrait](/physics/sites/default/files/styles/small/public/people/loren_hough_web.jpg?itok=Ul6cbHjY)
Associate Professor
Physics
°¿´Ú´Ú¾±³¦±ð:ÌýDUAN F527
Research Interests:
Professor Hough currently studies intrinsically disordered proteins using solution NMR. Proteins containing disordered domains perform many important cellular functions. The aggregations of this family of proteins is implicated in neuodegenerative diseases such as Alzheimer's and Parkinson's diseases. he has developed in-cell nuclear magnetic resonance techniques to study the disordered proteins that form the selective barrier of the nuclear pore complex. He is currently extending this in-cell method to study similar proteins, especially those involved in transcriptional regulation.
Selected Publications:
- "The role of competition in karyopherin-FG Nup interactions; a key to efficient transport through the nuclear pore complex", Jaclyn Tetenbaum-Novatt, Loren E. Hough, R. Mironska, AS McKenney, Michael Rout,ÌýMol Cell ProteomicsÌý11Ìý(5), 31-46 (May 2012).
- "Structure of the B4 Liquid Crystal Phase near a Glass Surface", Dong Chen, MS Heberling, M. Nakata, Loren E. Hough, JE Maclennan, MA Glaser, E. Korblova, DM Walba, J. Watanabe, Noel A. Clark,ÌýChemPhysChemÌý13, 155-159 (Jan 2012).
- "Interface structure of the dark conglomerate liquid crystal phase", Dong Chen, Yongqiang Shen, Chenhui Zhu, Loren E. Hough, Nlida Gimeno, Matthew A. Glaser, Joseph E. Maclennan, M. Blanca Ros, Noel A. Clark,ÌýSoft MatterÌý7, 1879-1883 (2011).
- "Chiral isotropic liquids from achiral molecules", Loren E. Hough, M. Spannuth, M. Nakata, D. A. Coleman, C. D. Jones, G. Dantlgraber, C. Tschierske, J. Watanabe, E. Krblova, D. M. Walba, J. E. Maclennan, M. A. Glaser, N. A. Clark,ÌýScienceÌý24, 452-456 (July 2009).
- "Helical nanofilament phases", L. E. Hough, H. T. Jung, D. Krerke, M. S. Heberling, M. Nakata, C. D. Jones, D. Chen, D. R. Link, J. Zasadzinski, G. Heppke, J. P. Rabe, W. Stocker, E. Krblova, D. M. Walba, M. A. Glaser, N. A. Clark,ÌýScienceÌý24, 456-460 (July 2009).
- "Microtubule depolymerization by the kinesin-8 motor Kip3p: a mathematical model", L. E. Hough, A. Schwabe, M. A. Glaser, J. R. McIntosh, and M. D. Betterton,ÌýBiophysical JournalÌý96, 3050 (2009).