Assistant Professor 鈥� Biomedical, Micro/Nanoscale, Thermo Fluid Sciences
Mechanical Engineering
Office Location:听ECES 158
Lab Location:听ECES 117
Research Interests
Biomedical microfluidics, intracellular delivery, drug delivery, lab on chip, cellular engineering
Xiaoyun Ding鈥檚 research group centers on the innovation of cutting-edge micro/nano systems for cell based biomedical applications, including micro/nano manipulation of cell and fluid, cell membrane disruption and repair, and precise intracellular/subcellular delivery. Our research is highly interdisciplinary at the frontiers of micro/nano engineering, biomedical engineering, acoustics, electronics, and other applied physics.听
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Societal Impact
We strive to improve human health and life quality through innovations in engineering cell functions for cell-based immunotherapy and reducing costs of disease diagnostics and therapeutics.
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Select Publications
- Gazendra听Shakya, Tao Yang, Yu Gao,听Apresio听K.听Fajrial,听Baowen听Li, Massimo Ruzzene, Mark A. Borden, and Xiaoyun Ding. Manipulating Internal Structure of听Endoskeletal听Droplets using Acoustic Waves.听Nature Communication, 13 (1), 1-9, (2022).
- Yu Gao,听Apresio听K听Fajrial, Tao Yang, Xiaoyun Ding. Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization,听Biomaterials Science,听9.5: 1574-1582. (2021). (Back听cover story)听
- Apresio听K.听Fajrial,听Kun听Liu, Yu Gao,听Junhao听Gu, Richard听Lakerveld, and Xiaoyun Ding. Characterization of single-cell osmotic swelling dynamics for new physical biomarkers,听Analytical Chemistry, 2020. (Front cover story)
- Apresio听Kefin听Fajrial, Qing听Qing听He, Nurul I.听Wirusanti, Jill听Slansky, and Xiaoyun Ding. A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing.听Theranostics, 10(12):5532-5549. (2020).
- Yonghui听Ding, Kerri A. Ball,听Kristofor听J. Webb, Yu Gao, Angelo D鈥橝lessandro, William M. Old, Michael H.B. Stowell, Xiaoyun Ding. On-chip听Acousto听Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability,听Small, 2003506, 2020. (Front Cover Story)
- Gazendra听Shakya, Samuel E. Hoff,听Shiyi听Wang, Hendrik Heinz, Xiaoyun Ding and Mark A. Borden. Vaporizableendoskeletal听droplets via tunable interfacial melting transitions.听Science Advances听6.14: eaaz7188,听(2020).
- Apresio听Fajrial, Xiaoyun Ding, Advanced Nanostructures for Cell Membrane听Poration.听Nanotechnology, 30, 264002, (2019)
- Xiaoyun Ding, Martin Stewart,听Armon听Sharei, James Weaver, Robert Langer, and听Klavs听Jensen,听Nature Biomedical Engineering, 1, 0039 (2017)
- Martin P Stewart,听Armon听Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer,听Klavs听F Jensen,听听Nature听538 (7624), 183-192 (2016)
- Xiaoyun Ding,听et al.,听PNAS,听111, 12992-12997 (2014).
- Xiaoyun Ding,听et al.,听Lab on a Chip, 13, 3626-3649 (2013).
- Xiaoyun Ding,听et al.,听听PNAS,听109, 11105-11109 (2012).
- Xiaoyun Ding,听et al.,听Lab on a Chip, 12, 4228鈥�4231 (2012). (Cover Image)
- Xiaoyun Ding,听et al.,听Lab on a Chip, 12, 2491-2497 (2012). (Cover image)
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Select Awards
- 2022听 The听Penn State Graduate School Alumni Society Early Career Award (1 awardee worldwide yearly)
- 2021听 NIH听MIRA Early Stage Investigator Award听
- 2021听 Bruce听S. Anderson Engineering Faculty Fellow, University of Colorado听
- 2020听 Chancellor's听Research Innovation Award, University of Colorado听
- 2020听 Lab听Venture Challenge 2020 winner, Colorado听
- 2020听 Biomaterials听Science Emerging Investigators 2021
- 2019听 W.听M. Keck Foundation Medical Research Grant Award
- 2019听 CCTSI听Novel Method Development Pilot Awards, Colorado
- 2013听听Rustum听and Della Roy Innovation in Materials Research Award, The Penn State University
- 2013听 Inventor听Incentive Award, The Penn State University
- 2013听 Journal听of Laboratory Automation Ten Breakthroughs in Innovation Award (JALA Ten 2013)
- 2012 听Student听Paper Competition Award, IEEE International听Ultrasonics听Symposium, Dresden, Germany听
- 2012 听The听Baxter Young Investigator Award, Chicago, USA (6 awardees nationwide)
- 2012 听First听Place Award at Penn State ESM Today Graduate Research Symposium, The Penn State University
- 2011 听Innovation听Award at Penn State ESM Today Graduate Research Symposium, 听The Penn State University